Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis

Colorectal cancer (CRC) cells are traditionally considered unresponsive to TGFβ due to mutations in the receptors and/or downstream signaling molecules. TGFβ influences CRC cells only indirectly via stromal cells, such as cancer-associated fibroblasts. However, CRC cell ability to directly respond t...

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Dettagli Bibliografici
Pubblicato in:Theranostics
Autori principali: Chiavarina, Barbara, Costanza, Brunella, Ronca, Roberto, Blomme, Arnaud, Rezzola, Sara, Chiodelli, Paola, Giguelay, Ambre, Belthier, Guillame, Doumont, Gilles, Van Simaeys, Gaetan, Lacroix, Simon, Yokobori, Takehiko, Erkhem-Ochir, Bilguun, Balaguer, Patrick, Cavailles, Vincent, Fabbrizio, Eric, Di Valentin, Emmanuel, Gofflot, Stephanie, Detry, Olivier, Jerusalem, Guy, Goldman, Serge, Delvenne, Philippe, Bellahcène, Akeila, Pannequin, Julie, Castronovo, Vincent, Turtoi, Andrei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2021
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778592/
https://ncbi.nlm.nih.gov/pubmed/33408771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.51507
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