Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition

Clinical practice reveals that osteoporotic women treated with BPs (bisphosphonates) show an increased bone mass density and a reduced risk of fractures. However, the mechanisms leading to these beneficial effects of BPs are still poorly understood. We hypothesized that ZOL (zoledronic acid), a pote...

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Bibliografiska uppgifter
Huvudupphovsmän: Chaplet, Michaël, Detry, Cédric, Deroanne, Christophe, Fisher, Larry W., Castronovo, Vincent, Bellahcéne, Akeila
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2004
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134145/
https://ncbi.nlm.nih.gov/pubmed/15324309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040380
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