Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis

Colorectal cancer (CRC) cells are traditionally considered unresponsive to TGFβ due to mutations in the receptors and/or downstream signaling molecules. TGFβ influences CRC cells only indirectly via stromal cells, such as cancer-associated fibroblasts. However, CRC cell ability to directly respond t...

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Vydáno v:Theranostics
Hlavní autoři: Chiavarina, Barbara, Costanza, Brunella, Ronca, Roberto, Blomme, Arnaud, Rezzola, Sara, Chiodelli, Paola, Giguelay, Ambre, Belthier, Guillame, Doumont, Gilles, Van Simaeys, Gaetan, Lacroix, Simon, Yokobori, Takehiko, Erkhem-Ochir, Bilguun, Balaguer, Patrick, Cavailles, Vincent, Fabbrizio, Eric, Di Valentin, Emmanuel, Gofflot, Stephanie, Detry, Olivier, Jerusalem, Guy, Goldman, Serge, Delvenne, Philippe, Bellahcène, Akeila, Pannequin, Julie, Castronovo, Vincent, Turtoi, Andrei
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778592/
https://ncbi.nlm.nih.gov/pubmed/33408771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.51507
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