The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma

p53 is an intensely studied tumor-suppressive transcription factor. Recent studies suggest that the RNA-binding protein (RBP) ZMAT3 is important in mediating the tumor-suppressive effects of p53. Here, we globally identify ZMAT3-regulated RNAs and their binding sites at nucleotide resolution in inta...

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Veröffentlicht in:Genes Dev
Hauptverfasser: Muys, Bruna R., Anastasakis, Dimitrios G., Claypool, Duncan, Pongor, Lörinc, Li, Xiao Ling, Grammatikakis, Ioannis, Liu, Minxue, Wang, Xiantao, Prasanth, Kannanganattu V., Aladjem, Mirit I., Lal, Ashish, Hafner, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778265/
https://ncbi.nlm.nih.gov/pubmed/33334821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.342634.120
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