DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress

Fanconi anemia (FA) is caused by defects in cellular responses to DNA crosslinking damage and replication stress. Given the constant occurrence of endogenous DNA damage and replication fork stress, it is unclear why complete deletion of FA genes does not have a major impact on cell proliferation and...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wang, Rui, Lenoir, Walter F., Wang, Chao, Su, Dan, McLaughlin, Megan, Hu, Qianghua, Shen, Xi, Tian, Yanyan, Klages-Mundt, Naeh, Lynn, Erica, Wood, Richard D., Chen, Junjie, Hart, Traver, Li, Lei
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7777187/
https://ncbi.nlm.nih.gov/pubmed/33376220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008821117
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