DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress

Fanconi anemia (FA) is caused by defects in cellular responses to DNA crosslinking damage and replication stress. Given the constant occurrence of endogenous DNA damage and replication fork stress, it is unclear why complete deletion of FA genes does not have a major impact on cell proliferation and...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Rui, Lenoir, Walter F., Wang, Chao, Su, Dan, McLaughlin, Megan, Hu, Qianghua, Shen, Xi, Tian, Yanyan, Klages-Mundt, Naeh, Lynn, Erica, Wood, Richard D., Chen, Junjie, Hart, Traver, Li, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7777187/
https://ncbi.nlm.nih.gov/pubmed/33376220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008821117
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