AG-348 (mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and adenosine triphosphate levels over a broad range of PKLR genotypes

Pyruvate kinase (PK) deficiency is a rare hereditary disorder affecting red blood cell (RBC) glycolysis, causing changes in metabolism including a deficiency in adenosine triphosphate (ATP). This affects red cell homeostasis, promoting premature removal of RBC from the circulation. In this study, we...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Rab, Minke A.E., van Oirschot, Brigitte A., Kosinski, Penelope A., Hixon, Jeffrey, Johnson, Kendall, Chubukov, Victor, Dang, Lenny, Pasterkamp, Gerard, van Straaten, Stephanie, van Solinge, Wouter W., van Beers, Eduard J., Kung, Charles, van Wijk, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Fondazione Ferrata Storti 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7776327/
https://ncbi.nlm.nih.gov/pubmed/31974203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.238865
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