Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population

Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. We have shown that Pklr deficiency in mice reduces the severity (reduced parasitemia, increased survival) of blood stage malaria induced by infection with Plasmodium chabaudi AS. Likewise,...

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Vydáno v:PLoS One
Hlavní autoři: van Bruggen, Rebekah, Gualtieri, Christian, Iliescu, Alexandra, Louicharoen Cheepsunthorn, Chalisa, Mungkalasut, Punchalee, Trape, Jean-François, Modiano, David, Sodiomon Sirima, Bienvenu, Singhasivanon, Pratap, Lathrop, Mark, Sakuntabhai, Anavaj, Bureau, Jean-François, Gros, Philippe
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677815/
https://ncbi.nlm.nih.gov/pubmed/26658699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144555
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