Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

BACKGROUND: Deciphering the genetic architecture of complex traits is still a major challenge for human genetics. In most cases, genome-wide association studies have only partially explained the heritability of traits and diseases. Epistasis, one potentially important cause of this missing heritabil...

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Pubblicato in:BMC Genet
Autori principali: Grange, Laura, Bureau, Jean-François, Nikolayeva, Iryna, Paul, Richard, Van Steen, Kristel, Schwikowski, Benno, Sakuntabhai, Anavaj
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Methodology Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341885/
https://ncbi.nlm.nih.gov/pubmed/25655172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12863-015-0174-3
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