The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model

Anemia in β-thalassemia is related to ineffective erythropoiesis and reduced red cell survival. Excess free heme and accumulation of unpaired α-globin chains impose substantial oxidative stress on β-thalassemic erythroblasts and erythrocytes, impacting cell metabolism. We hypothesized that increased...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Matte, Alessandro, Federti, Enrica, Kung, Charles, Kosinski, Penelope A., Narayanaswamy, Rohini, Russo, Roberta, Federico, Giorgia, Carlomagno, Francesca, Desbats, Maria Andrea, Salviati, Leonardo, Leboeuf, Christophe, Valenti, Maria Teresa, Turrini, Francesco, Janin, Anne, Yu, Shaoxia, Beneduce, Elisabetta, Ronseaux, Sebastien, Iatcenko, Iana, Dang, Lenny, Ganz, Tomas, Jung, Chun-Ling, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2021
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121526/
https://ncbi.nlm.nih.gov/pubmed/33822774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI144206
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk