The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model

Anemia in β-thalassemia is related to ineffective erythropoiesis and reduced red cell survival. Excess free heme and accumulation of unpaired α-globin chains impose substantial oxidative stress on β-thalassemic erythroblasts and erythrocytes, impacting cell metabolism. We hypothesized that increased...

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Udgivet i:J Clin Invest
Main Authors: Matte, Alessandro, Federti, Enrica, Kung, Charles, Kosinski, Penelope A., Narayanaswamy, Rohini, Russo, Roberta, Federico, Giorgia, Carlomagno, Francesca, Desbats, Maria Andrea, Salviati, Leonardo, Leboeuf, Christophe, Valenti, Maria Teresa, Turrini, Francesco, Janin, Anne, Yu, Shaoxia, Beneduce, Elisabetta, Ronseaux, Sebastien, Iatcenko, Iana, Dang, Lenny, Ganz, Tomas, Jung, Chun-Ling, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121526/
https://ncbi.nlm.nih.gov/pubmed/33822774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI144206
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