HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development

In both mouse and human, Notch1 activation is the main initial driver to induce T-cell development in hematopoietic progenitor cells. The initiation of this developmental process coincides with Notch1-dependent repression of differentiation towards other hematopoietic lineages. Although well describ...

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Pubblicato in:Haematologica
Autori principali: De Decker, Matthias, Lavaert, Marieke, Roels, Juliette, Tilleman, Laurentijn, Vandekerckhove, Bart, Leclercq, Georges, Van Nieuwerburgh, Filip, Van Vlierberghe, Pieter, Taghon, Tom
Natura: Artigo
Lingua:Inglês
Pubblicazione: Fondazione Ferrata Storti 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7776241/
https://ncbi.nlm.nih.gov/pubmed/31919081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.226126
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