SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

The spike aspartic acid–614 to glycine (D614G) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral pathogenesis and transmissibility remain unclear. We engineered a SARS-CoV-2 variant containing this substitution. The var...

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Xehetasun bibliografikoak
Argitaratua izan da:Science
Egile Nagusiak: Hou, Yixuan J., Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, Kenneth H., Leist, Sarah R., Schäfer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E., Mascenik, Teresa M., Graham, Rachel, Edwards, Caitlin E., Tse, Longping V., Okuda, Kenichi, Markmann, Alena J., Bartelt, Luther, de Silva, Aravinda, Margolis, David M., Boucher, Richard C., Randell, Scott H., Suzuki, Tadaki, Gralinski, Lisa E., Kawaoka, Yoshihiro, Baric, Ralph S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Association for the Advancement of Science 2020
Gaiak:
Reports
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775736/
https://ncbi.nlm.nih.gov/pubmed/33184236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abe8499
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