SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo

The D614G substitution in the S protein is most prevalent SARS-CoV-2 strain circulating globally, but its effects in viral pathogenesis and transmission remain unclear. We engineered SARS-CoV-2 variants harboring the D614G substitution with or without nanoluciferase. The D614G variant replicates mor...

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Библиографические подробности
Опубликовано в: :bioRxiv
Главные авторы: Hou, Yixuan J., Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, Kenneth H, Leist, Sarah R., Schäfer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E., Mascenik, Teresa M., Edwards, Caitlin E., Tse, Longping V., Boucher, Richard C., Randell, Scott H., Suzuki, Tadaki, Gralinski, Lisa E., Kawaoka, Yoshihiro, Baric, Ralph S.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536872/
https://ncbi.nlm.nih.gov/pubmed/33024969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.09.28.317685
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