A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures multiple aspects of severe COVID-19 disease in standard laboratory mice. This SARS-CoV-2 model exhibits the spectrum of morbidity and mortal...

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發表在:Cell
Main Authors: Leist, Sarah R., Dinnon, Kenneth H., Schäfer, Alexandra, Tse, Longping V., Okuda, Kenichi, Hou, Yixuan J., West, Ande, Edwards, Caitlin E., Sanders, Wes, Fritch, Ethan J., Gully, Kendra L., Scobey, Trevor, Brown, Ariane J., Sheahan, Timothy P., Moorman, Nathaniel J., Boucher, Richard C., Gralinski, Lisa E., Montgomery, Stephanie A., Baric, Ralph S.
格式: Artigo
語言:Inglês
出版: Elsevier Inc. 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510428/
https://ncbi.nlm.nih.gov/pubmed/33031744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.09.050
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