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Widespread Transcriptional Readthrough Caused by Nab2 Depletion Leads to Chimeric Transcripts with Retained Introns

Nascent RNA sequencing has revealed that pre-mRNA splicing can occur shortly after introns emerge from RNA polymerase II (RNA Pol II). Differences in co-transcriptional splicing profiles suggest regulation by cis-and/or trans-acting factors. Here, we use single-molecule intron tracking (SMIT) to ide...

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Foilsithe in:Cell Rep
Main Authors: Alpert, Tara, Straube, Korinna, Oesterreich, Fernando Carrillo, Neugebauer, Karla M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774305/
https://ncbi.nlm.nih.gov/pubmed/33113357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108324
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