Targeted Apoptosis of Ductular Reactive Cells Reduces Hepatic Fibrosis in a Mouse Model of Cholestasis

BACKGROUND AND AIMS: In cholestatic liver diseases, ductular reactive (DR) cells extend into the hepatic parenchyma and promote inflammation and fibrosis. We have previously observed that multidrug-resistant 2 (Mdr2(−/−)) double knockout (DKO) mice lacking tumor necrosis factor–related apoptosis-ind...

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Bibliografiset tiedot
Julkaisussa:Hepatology
Päätekijät: Azad, Adiba I., Krishnan, Anuradha, Troop, Leia, Li, Ying, Katsumi, Tomohiro, Pavelko, Kevin, Kostallari, Enis, Guicciardi, Maria Eugenia, Gores, Gregory J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774262/
https://ncbi.nlm.nih.gov/pubmed/32128842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31211
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