Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

Although a lysosomal, cathepsin B–dependent (Ctsb-dependent) pathway of apoptosis has been described, the contribution of this pathway to tissue damage remains unclear. Our aim was to ascertain if Ctsb inactivation attenuates liver injury, inflammation, and fibrogenesis after bile duct ligation (BDL...

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Bibliografiska uppgifter

I publikationen:	J Clin Invest
Huvudupphov:	Canbay, Ali, Guicciardi, Maria Eugenia, Higuchi, Hajime, Feldstein, Ariel, Bronk, Steven F., Rydzewski, Robert, Taniai, Makiko, Gores, Gregory J.
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	American Society for Clinical Investigation 2003
Ämnen:	Article
Länkar:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164289/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12865404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI17740
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