Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

Although a lysosomal, cathepsin B–dependent (Ctsb-dependent) pathway of apoptosis has been described, the contribution of this pathway to tissue damage remains unclear. Our aim was to ascertain if Ctsb inactivation attenuates liver injury, inflammation, and fibrogenesis after bile duct ligation (BDL...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	J Clin Invest
Autori principali:	Canbay, Ali, Guicciardi, Maria Eugenia, Higuchi, Hajime, Feldstein, Ariel, Bronk, Steven F., Rydzewski, Robert, Taniai, Makiko, Gores, Gregory J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2003
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164289/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12865404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI17740
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!