Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

Although a lysosomal, cathepsin B–dependent (Ctsb-dependent) pathway of apoptosis has been described, the contribution of this pathway to tissue damage remains unclear. Our aim was to ascertain if Ctsb inactivation attenuates liver injury, inflammation, and fibrogenesis after bile duct ligation (BDL...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Canbay, Ali, Guicciardi, Maria Eugenia, Higuchi, Hajime, Feldstein, Ariel, Bronk, Steven F., Rydzewski, Robert, Taniai, Makiko, Gores, Gregory J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2003
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164289/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12865404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI17740
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