Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

Although a lysosomal, cathepsin B–dependent (Ctsb-dependent) pathway of apoptosis has been described, the contribution of this pathway to tissue damage remains unclear. Our aim was to ascertain if Ctsb inactivation attenuates liver injury, inflammation, and fibrogenesis after bile duct ligation (BDL...

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Bibliografische gegevens

Gepubliceerd in:	J Clin Invest
Hoofdauteurs:	Canbay, Ali, Guicciardi, Maria Eugenia, Higuchi, Hajime, Feldstein, Ariel, Bronk, Steven F., Rydzewski, Robert, Taniai, Makiko, Gores, Gregory J.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Clinical Investigation 2003
Onderwerpen:	Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164289/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12865404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI17740
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