Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

Although a lysosomal, cathepsin B–dependent (Ctsb-dependent) pathway of apoptosis has been described, the contribution of this pathway to tissue damage remains unclear. Our aim was to ascertain if Ctsb inactivation attenuates liver injury, inflammation, and fibrogenesis after bile duct ligation (BDL...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Canbay, Ali, Guicciardi, Maria Eugenia, Higuchi, Hajime, Feldstein, Ariel, Bronk, Steven F., Rydzewski, Robert, Taniai, Makiko, Gores, Gregory J.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 2003
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164289/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12865404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI17740
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