Targeted Apoptosis of Ductular Reactive Cells Reduces Hepatic Fibrosis in a Mouse Model of Cholestasis

BACKGROUND AND AIMS: In cholestatic liver diseases, ductular reactive (DR) cells extend into the hepatic parenchyma and promote inflammation and fibrosis. We have previously observed that multidrug-resistant 2 (Mdr2(−/−)) double knockout (DKO) mice lacking tumor necrosis factor–related apoptosis-ind...

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Publicado en:Hepatology
Main Authors: Azad, Adiba I., Krishnan, Anuradha, Troop, Leia, Li, Ying, Katsumi, Tomohiro, Pavelko, Kevin, Kostallari, Enis, Guicciardi, Maria Eugenia, Gores, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774262/
https://ncbi.nlm.nih.gov/pubmed/32128842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31211
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