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Targeted Apoptosis of Ductular Reactive Cells Reduces Hepatic Fibrosis in a Mouse Model of Cholestasis
BACKGROUND AND AIMS: In cholestatic liver diseases, ductular reactive (DR) cells extend into the hepatic parenchyma and promote inflammation and fibrosis. We have previously observed that multidrug-resistant 2 (Mdr2(−/−)) double knockout (DKO) mice lacking tumor necrosis factor–related apoptosis-ind...
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| Veröffentlicht in: | Hepatology |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7774262/ https://ncbi.nlm.nih.gov/pubmed/32128842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31211 |
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