CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

Cytokines are highly pleiotropic ligands that regulate the immune response. Here, using interleukin-6 (IL-6) as a model system, we perform detailed phosphoproteomic and transcriptomic studies in human CD4(+) T helper 1 (Th-1) cells to address the molecular bases defining cytokine functional pleiotro...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Martinez-Fabregas, Jonathan, Wang, Luopin, Pohler, Elizabeth, Cozzani, Adeline, Wilmes, Stephan, Kazemian, Majid, Mitra, Suman, Moraga, Ignacio
Format: Artigo
Language:Inglês
Published: Cell Press 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773550/
https://ncbi.nlm.nih.gov/pubmed/33357429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108545
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