Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

Interleukin-10 (IL-10) is a dimeric cytokine with both immunosuppressive and immunostimulatory activities; however, IL-10-based therapies have shown only marginal clinical benefits. Here, we explored whether the stability of the IL-10-receptor complex contributes to the immunomodulatory potency of I...

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Gepubliceerd in:Sci Signal
Hoofdauteurs: Gorby, Claire, Bellón, Junel Sotolongo, Wilmes, Stephan, Warda, Walid, Pohler, Elizabeth, Fyfe, Paul K., Cozzani, Adeline, Ferrand, Christophe, Walter, Mark R., Mitra, Suman, Piehler, Jacob, Moraga, Ignacio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685028/
https://ncbi.nlm.nih.gov/pubmed/32934073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abc0653
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