Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine–induced lncRNA Morrbid

Diabetes mellitus (DM) is a risk factor for cancer. The role of DM-induced hyperglycemic (HG) stress in blood cancer is poorly understood. Epidemiologic studies show that individuals with DM are more likely to have a higher rate of mutations in genes found in pre-leukemic hematopoietic stem and prog...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Cai, Zhigang, Lu, Xiaoyu, Zhang, Chi, Nelanuthala, Sai, Aguilera, Fabiola, Hadley, Abigail, Ramdas, Baskar, Fang, Fang, Nephew, Kenneth, Kotzin, Jonathan J., Williams, Adam, Henao-Mejia, Jorge, Haneline, Laura, Kapur, Reuben
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
Materias:
Concise Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773407/
https://ncbi.nlm.nih.gov/pubmed/33090974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140707
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