Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress Induced Abnormalities and Clonal Hematopoiesis

Inflammation is a risk factor for cancer development. Individuals with preleukemic TET2 mutations manifest clonal hematopoiesis and are at a higher risk of developing leukemia. How inflammatory signals influence the survival of preleukemic hematopoietic stem and progenitor cells (preleukemic-HSPCs)...

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Publicado no:Cell Stem Cell
Main Authors: Cai, Zhigang, Kotzin, Jonathan J., Ramdas, Baskar, Chen, Sisi, Nelanuthala, Sai, Palam, Lakshmi Reddy, Pandey, Ruchi, Mali, Raghuveer Singh, Liu, Yan, Kelley, Mark R., Sandusky, George, Mohseni, Morvarid, Williams, Adam, Henao-Mejia, Jorge, Kapur, Reuben
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317370/
https://ncbi.nlm.nih.gov/pubmed/30526882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.10.013
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