Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction

Graft-versus-host disease (GVHD) causes failed reconstitution of donor plasmacytoid dendritic cells (pDCs) that are critical for immune protection and tolerance. We used both murine and human systems to uncover the mechanisms whereby GVHD induces donor pDC defects. GVHD depleted Flt3-expressing dono...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Tian, Yuanyuan, Meng, Lijun, Wang, Ying, Li, Bohan, Yu, Hongshuang, Zhou, Yan, Bui, Tien, Abraham, Ciril, Li, Alicia, Zhang, Yongping, Wang, Jian, Zhao, Chenchen, Mineishi, Shin, Gallucci, Stefania, Porter, David, Hexner, Elizabeth, Zheng, Hong, Zhang, Yanyun, Hu, Shaoyan, Zhang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773406/
https://ncbi.nlm.nih.gov/pubmed/33090973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136774
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