Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction

Graft-versus-host disease (GVHD) causes failed reconstitution of donor plasmacytoid dendritic cells (pDCs) that are critical for immune protection and tolerance. We used both murine and human systems to uncover the mechanisms whereby GVHD induces donor pDC defects. GVHD depleted Flt3-expressing dono...

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Publicado en:J Clin Invest
Autores principales: Tian, Yuanyuan, Meng, Lijun, Wang, Ying, Li, Bohan, Yu, Hongshuang, Zhou, Yan, Bui, Tien, Abraham, Ciril, Li, Alicia, Zhang, Yongping, Wang, Jian, Zhao, Chenchen, Mineishi, Shin, Gallucci, Stefania, Porter, David, Hexner, Elizabeth, Zheng, Hong, Zhang, Yanyun, Hu, Shaoyan, Zhang, Yi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773406/
https://ncbi.nlm.nih.gov/pubmed/33090973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136774
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