Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction

Graft-versus-host disease (GVHD) causes failed reconstitution of donor plasmacytoid dendritic cells (pDCs) that are critical for immune protection and tolerance. We used both murine and human systems to uncover the mechanisms whereby GVHD induces donor pDC defects. GVHD depleted Flt3-expressing dono...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Tian, Yuanyuan, Meng, Lijun, Wang, Ying, Li, Bohan, Yu, Hongshuang, Zhou, Yan, Bui, Tien, Abraham, Ciril, Li, Alicia, Zhang, Yongping, Wang, Jian, Zhao, Chenchen, Mineishi, Shin, Gallucci, Stefania, Porter, David, Hexner, Elizabeth, Zheng, Hong, Zhang, Yanyun, Hu, Shaoyan, Zhang, Yi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773406/
https://ncbi.nlm.nih.gov/pubmed/33090973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136774
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