Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation

Macrophages are main effectors of heme metabolism, increasing transiently in the liver during heightened disposal of damaged or senescent RBCs (sRBCs). Macrophages are also essential in defense against microbial threats, but pathological states of heme excess may be immunosuppressive. Herein, we unc...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Olonisakin, Tolani F., Suber, Tomeka, Gonzalez-Ferrer, Shekina, Xiong, Zeyu, Peñaloza, Hernán F., van der Geest, Rick, Xiong, Yuting, Osei-Hwedieh, David O., Tejero, Jesús, Rosengart, Matthew R., Mars, Wendy M., Van Tyne, Daria, Perlegas, Andreas, Brashears, Samuel, Kim-Shapiro, Daniel B., Gladwin, Mark T., Bachman, Michael A., Hod, Eldad A., St. Croix, Claudette, Tyurina, Yulia Y., Kagan, Valerian E., Mallampalli, Rama K., Ray, Anuradha, Ray, Prabir, Lee, Janet S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773401/
https://ncbi.nlm.nih.gov/pubmed/32941182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137468
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares