Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation

Macrophages are main effectors of heme metabolism, increasing transiently in the liver during heightened disposal of damaged or senescent RBCs (sRBCs). Macrophages are also essential in defense against microbial threats, but pathological states of heme excess may be immunosuppressive. Herein, we unc...

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Publié dans:J Clin Invest
Auteurs principaux: Olonisakin, Tolani F., Suber, Tomeka, Gonzalez-Ferrer, Shekina, Xiong, Zeyu, Peñaloza, Hernán F., van der Geest, Rick, Xiong, Yuting, Osei-Hwedieh, David O., Tejero, Jesús, Rosengart, Matthew R., Mars, Wendy M., Van Tyne, Daria, Perlegas, Andreas, Brashears, Samuel, Kim-Shapiro, Daniel B., Gladwin, Mark T., Bachman, Michael A., Hod, Eldad A., St. Croix, Claudette, Tyurina, Yulia Y., Kagan, Valerian E., Mallampalli, Rama K., Ray, Anuradha, Ray, Prabir, Lee, Janet S.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773401/
https://ncbi.nlm.nih.gov/pubmed/32941182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137468
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