The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

Bacterial pneumonia is a significant healthcare burden worldwide. Failure to resolve inflammation after infection precipitates lung injury and an increase in morbidity and mortality. Gram-negative bacteria are common in pneumonia and increased levels of the mito-damage-associated molecular pattern (...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Chakraborty, Krishnendu, Raundhal, Mahesh, Chen, Bill B., Morse, Christina, Tyurina, Yulia Y., Khare, Anupriya, Oriss, Timothy B., Huff, Rachael, Lee, Janet S., St. Croix, Claudette M., Watkins, Simon, Mallampalli, Rama K., Kagan, Valerian E., Ray, Anuradha, Ray, Prabir
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241690/
https://ncbi.nlm.nih.gov/pubmed/28074841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13944
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