The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

Bacterial pneumonia is a significant healthcare burden worldwide. Failure to resolve inflammation after infection precipitates lung injury and an increase in morbidity and mortality. Gram-negative bacteria are common in pneumonia and increased levels of the mito-damage-associated molecular pattern (...

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Udgivet i:Nat Commun
Main Authors: Chakraborty, Krishnendu, Raundhal, Mahesh, Chen, Bill B., Morse, Christina, Tyurina, Yulia Y., Khare, Anupriya, Oriss, Timothy B., Huff, Rachael, Lee, Janet S., St. Croix, Claudette M., Watkins, Simon, Mallampalli, Rama K., Kagan, Valerian E., Ray, Anuradha, Ray, Prabir
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241690/
https://ncbi.nlm.nih.gov/pubmed/28074841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13944
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