High IFN-γ and low SLPI mark severe asthma in mice and humans

Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of systemic corticosteroids (CS). In contrast, mild-moderate asthma (MMA) is responsive to low doses of inhaled CS, indicating that Th2 cells, which are dominant in MMA, do not solely orchestrate SA developmen...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Raundhal, Mahesh, Morse, Christina, Khare, Anupriya, Oriss, Timothy B., Milosevic, Jadranka, Trudeau, John, Huff, Rachael, Pilewski, Joseph, Holguin, Fernando, Kolls, Jay, Wenzel, Sally, Ray, Prabir, Ray, Anuradha
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563754/
https://ncbi.nlm.nih.gov/pubmed/26121748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80911
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