Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines

As the interface between the gut microbiota and the mucosal immune system, there has been great interest in the maintenance of colonic epithelial integrity through mitochondrial oxidation of butyrate, a short-chain fatty acid produced by the gut microbiota. Herein, we showed that the intestinal epit...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Smith, Sarah A., Ogawa, Sayaka A., Chau, Lillian, Whelan, Kelly A., Hamilton, Kathryn E., Chen, Jie, Tan, Lu, Chen, Eric Z., Keilbaugh, Sue, Fogt, Franz, Bewtra, Meenakshi, Braun, Jonathan, Xavier, Ramnik J., Clish, Clary B., Slaff, Barry, Weljie, Aalim M., Bushman, Frederic D., Lewis, James D., Li, Hongzhe, Master, Stephen R., Bennett, Michael J., Nakagawa, Hiroshi, Wu, Gary D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773399/
https://ncbi.nlm.nih.gov/pubmed/33141762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133371
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