Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines

As the interface between the gut microbiota and the mucosal immune system, there has been great interest in the maintenance of colonic epithelial integrity through mitochondrial oxidation of butyrate, a short-chain fatty acid produced by the gut microbiota. Herein, we showed that the intestinal epit...

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Pubblicato in:J Clin Invest
Autori principali: Smith, Sarah A., Ogawa, Sayaka A., Chau, Lillian, Whelan, Kelly A., Hamilton, Kathryn E., Chen, Jie, Tan, Lu, Chen, Eric Z., Keilbaugh, Sue, Fogt, Franz, Bewtra, Meenakshi, Braun, Jonathan, Xavier, Ramnik J., Clish, Clary B., Slaff, Barry, Weljie, Aalim M., Bushman, Frederic D., Lewis, James D., Li, Hongzhe, Master, Stephen R., Bennett, Michael J., Nakagawa, Hiroshi, Wu, Gary D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773399/
https://ncbi.nlm.nih.gov/pubmed/33141762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133371
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