Human skin is colonized by T cells that recognize CD1a independently of lipid

CD1a-autoreactive T cells contribute to skin disease, but the identity of immunodominant self-lipid antigens and their mode of recognition are not yet solved. In most models, MHC and CD1 proteins serve as display platforms for smaller antigens. Here, we showed that CD1a tetramers without added antig...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cotton, Rachel N., Cheng, Tan-Yun, Wegrecki, Marcin, Le Nours, Jérôme, Orgill, Dennis P., Pomahac, Bohdan, Talbot, Simon G., Willis, Richard A., Altman, John D., de Jong, Annemieke, Ogg, Graham, Van Rhijn, Ildiko, Rossjohn, Jamie, Clark, Rachael A., Moody, D. Branch
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773353/
https://ncbi.nlm.nih.gov/pubmed/33393500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140706
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