CD1a selectively captures endogenous cellular lipids that broadly block T cell response

We optimized lipidomics methods to broadly detect endogenous lipids bound to cellular CD1a proteins. Whereas membrane phospholipids dominate in cells, CD1a preferentially captured sphingolipids, especially a C42, doubly unsaturated sphingomyelin (42:2 SM). The natural 42:2 SM but not the more common...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Cotton, Rachel N., Wegrecki, Marcin, Cheng, Tan-Yun, Chen, Yi-Ling, Veerapen, Natacha, Le Nours, Jérôme, Orgill, Dennis P., Pomahac, Bohdan, Talbot, Simon G., Willis, Richard, Altman, John D., de Jong, Annemieke, Van Rhijn, Ildiko, Clark, Rachael A., Besra, Gurdyal S., Ogg, Graham, Rossjohn, Jamie, Moody, D. Branch
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111460/
https://ncbi.nlm.nih.gov/pubmed/33961028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202699
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