CD1a selectively captures endogenous cellular lipids that broadly block T cell response

We optimized lipidomics methods to broadly detect endogenous lipids bound to cellular CD1a proteins. Whereas membrane phospholipids dominate in cells, CD1a preferentially captured sphingolipids, especially a C42, doubly unsaturated sphingomyelin (42:2 SM). The natural 42:2 SM but not the more common...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Cotton, Rachel N., Wegrecki, Marcin, Cheng, Tan-Yun, Chen, Yi-Ling, Veerapen, Natacha, Le Nours, Jérôme, Orgill, Dennis P., Pomahac, Bohdan, Talbot, Simon G., Willis, Richard, Altman, John D., de Jong, Annemieke, Van Rhijn, Ildiko, Clark, Rachael A., Besra, Gurdyal S., Ogg, Graham, Rossjohn, Jamie, Moody, D. Branch
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111460/
https://ncbi.nlm.nih.gov/pubmed/33961028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202699
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