Structural determination of lipid antigens captured at the CD1d–T-cell receptor interface

Glycolipid antigens recognized by αβ T-cell receptors (TCRs) drive the activation of invariant natural killer T (iNKT) cells, a specialized subset of innate T lymphocytes. Glycolipids with α-linked anomeric carbohydrates have been identified as potent microbial lipid antigens for iNKT cells, and the...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Brennan, Patrick J., Cheng, Tan-Yun, Pellicci, Daniel G., Watts, Gerald F. M., Veerapen, Natacha, Young, David C., Rossjohn, Jamie, Besra, Gurdyal S., Godfrey, Dale I., Brenner, Michael B., Moody, D. Branch
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547638/
https://ncbi.nlm.nih.gov/pubmed/28716901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705882114
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