CD1a autoreactive T cells recognize natural skin oils that function as headless antigens

CD1a autoreactive T cells are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids. After capturing CD1a-lipid complexes, we gently eluted ligands, while preserving unliganded CD1a for testing lipid...

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Detalhes bibliográficos
Main Authors: de Jong, Annemieke, Cheng, Tan-Yun, Huang, Shouxiong, Gras, Stephanie, Birkinshaw, Richard W., Kasmar, Anne, van Rhijn, Ildiko, Peña-Cruz, Victor, Ruan, Daniel T., Altman, John D., Rossjohn, Jamie, Moody, D. Branch
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932764/
https://ncbi.nlm.nih.gov/pubmed/24362891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2790
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