Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants

Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional interpretation. Because regulatory sequences often reside in open chromatin, we reasoned that neuropsychiatric disease risk variants may affect chromatin accessibility during neurodevelopment. Using human indu...

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Vydáno v:Science
Hlavní autoři: Zhang, Siwei, Zhang, Hanwen, Zhou, Yifan, Qiao, Min, Zhao, Siming, Kozlova, Alena, Shi, Jianxin, Sanders, Alan R., Wang, Gao, Luo, Kaixuan, Sengupta, Subhajit, West, Siobhan, Qian, Sheng, Streit, Michael, Avramopoulos, Dimitrios, Cowan, Chad A., Chen, Mengjie, Pang, Zhiping P., Gejman, Pablo V., He, Xin, Duan, Jubao
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773145/
https://ncbi.nlm.nih.gov/pubmed/32732423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay3983
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