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Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants

Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional interpretation. Because regulatory sequences often reside in open chromatin, we reasoned that neuropsychiatric disease risk variants may affect chromatin accessibility during neurodevelopment. Using human indu...

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הוצא לאור ב:	Science
Main Authors:	Zhang, Siwei, Zhang, Hanwen, Zhou, Yifan, Qiao, Min, Zhao, Siming, Kozlova, Alena, Shi, Jianxin, Sanders, Alan R., Wang, Gao, Luo, Kaixuan, Sengupta, Subhajit, West, Siobhan, Qian, Sheng, Streit, Michael, Avramopoulos, Dimitrios, Cowan, Chad A., Chen, Mengjie, Pang, Zhiping P., Gejman, Pablo V., He, Xin, Duan, Jubao
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2020
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7773145/ https://ncbi.nlm.nih.gov/pubmed/32732423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay3983
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Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants

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