Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants

Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional interpretation. Because regulatory sequences often reside in open chromatin, we reasoned that neuropsychiatric disease risk variants may affect chromatin accessibility during neurodevelopment. Using human indu...

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Publicado no:Science
Main Authors: Zhang, Siwei, Zhang, Hanwen, Zhou, Yifan, Qiao, Min, Zhao, Siming, Kozlova, Alena, Shi, Jianxin, Sanders, Alan R., Wang, Gao, Luo, Kaixuan, Sengupta, Subhajit, West, Siobhan, Qian, Sheng, Streit, Michael, Avramopoulos, Dimitrios, Cowan, Chad A., Chen, Mengjie, Pang, Zhiping P., Gejman, Pablo V., He, Xin, Duan, Jubao
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773145/
https://ncbi.nlm.nih.gov/pubmed/32732423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay3983
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