Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants

Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional interpretation. Because regulatory sequences often reside in open chromatin, we reasoned that neuropsychiatric disease risk variants may affect chromatin accessibility during neurodevelopment. Using human indu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Zhang, Siwei, Zhang, Hanwen, Zhou, Yifan, Qiao, Min, Zhao, Siming, Kozlova, Alena, Shi, Jianxin, Sanders, Alan R., Wang, Gao, Luo, Kaixuan, Sengupta, Subhajit, West, Siobhan, Qian, Sheng, Streit, Michael, Avramopoulos, Dimitrios, Cowan, Chad A., Chen, Mengjie, Pang, Zhiping P., Gejman, Pablo V., He, Xin, Duan, Jubao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773145/
https://ncbi.nlm.nih.gov/pubmed/32732423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay3983
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