Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation

Aub guided by piRNAs ensures genome integrity by cleaving retrotransposons, and genome propagation by trapping mRNAs to form the germplasm that instructs germ cell formation. Arginines at the N-terminus of Aub (Aub–NTRs) interact with Tudor and other Tudor domain–containing proteins (TDRDs). Aub–TDR...

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Foilsithe in:Life Sci Alliance
Main Authors: Vrettos, Nicholas, Maragkakis, Manolis, Alexiou, Panagiotis, Sgourdou, Paraskevi, Ibrahim, Fadia, Palmieri, Daniel, Kirino, Yohei, Mourelatos, Zissimos
Formáid: Artigo
Teanga:Inglês
Foilsithe: Life Science Alliance LLC 2020
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772777/
https://ncbi.nlm.nih.gov/pubmed/33376130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000912
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