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Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis

Messenger RNAs transmit the genetic information that dictates protein production, and are a nexus for numerous pathways that regulate gene expression. The prevailing view of canonical mRNA decay is that it is mediated by deadenylation and decapping followed by exonucleolysis from the 3′ and 5′ ends....

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Библиографические подробности
Опубликовано в: :Nat Struct Mol Biol
Главные авторы: Ibrahim, Fadia, Maragkakis, Manolis, Alexiou, Panagiotis, Mourelatos, Zissimos
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889319/
https://ncbi.nlm.nih.gov/pubmed/29507394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0042-8
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