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Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis

Messenger RNAs transmit the genetic information that dictates protein production, and are a nexus for numerous pathways that regulate gene expression. The prevailing view of canonical mRNA decay is that it is mediated by deadenylation and decapping followed by exonucleolysis from the 3′ and 5′ ends....

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Ibrahim, Fadia, Maragkakis, Manolis, Alexiou, Panagiotis, Mourelatos, Zissimos
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889319/
https://ncbi.nlm.nih.gov/pubmed/29507394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0042-8
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