Fluorofenidone Alleviates Renal Fibrosis by Inhibiting Necroptosis Through RIPK3/MLKL Pathway

Cell death and sterile inflammation are major mechanisms of renal fibrosis, which eventually develop into end-stage renal disease. “Necroptosis” is a type of caspase-independent regulated cell death, and sterile inflammatory response caused by tissue injury is strongly related to necrosis. Fluorofen...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Dai, Qin, Zhang, Yan, Liao, Xiaohua, Jiang, Yupeng, Lv, Xin, Yuan, Xiangning, Meng, Jie, Xie, Yanyun, Peng, Zhangzhe, Yuan, Qiongjing, Tao, LiJian, Huang, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772387/
https://ncbi.nlm.nih.gov/pubmed/33390935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.534775
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