A Mendelian randomization of γ′ and total fibrinogen levels in relation to venous thromboembolism and ischemic stroke

Fibrinogen is a key component of the coagulation cascade, and variation in its circulating levels may contribute to thrombotic diseases, such as venous thromboembolism (VTE) and ischemic stroke. Gamma prime (γ′) fibrinogen is an isoform of fibrinogen that has anticoagulant properties. We applied 2-s...

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Publicado en:Blood
Autores principales: Maners, Jillian, Gill, Dipender, Pankratz, Nathan, Laffan, Michael A., Wolberg, Alisa S., de Maat, Moniek P. M., Ligthart, Symen, Tang, Weihong, Ward-Caviness, Cavin K., Fornage, Myriam, Debette, Stephanie, Dichgans, Martin, McKnight, Barbara, Boerwinkle, Eric, Smith, Nicholas L., Morrison, Alanna C., Dehghan, Abbas, de Vries, Paul S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2020
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7770565/
https://ncbi.nlm.nih.gov/pubmed/33367543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004781
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