Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease

BACKGROUND: Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not...

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Veröffentlicht in:PLoS One
Hauptverfasser: Ward-Caviness, Cavin K., de Vries, Paul S., Wiggins, Kerri L., Huffman, Jennifer E., Yanek, Lisa R., Bielak, Lawrence F., Giulianini, Franco, Guo, Xiuqing, Kleber, Marcus E., Kacprowski, Tim, Groß, Stefan, Petersman, Astrid, Davey Smith, George, Hartwig, Fernando P., Bowden, Jack, Hemani, Gibran, Müller-Nuraysid, Martina, Strauch, Konstantin, Koenig, Wolfgang, Waldenberger, Melanie, Meitinger, Thomas, Pankratz, Nathan, Boerwinkle, Eric, Tang, Weihong, Fu, Yi-Ping, Johnson, Andrew D., Song, Ci, de Maat, Moniek P. M., Uitterlinden, André G., Franco, Oscar H., Brody, Jennifer A., McKnight, Barbara, Chen, Yii-Der Ida, Psaty, Bruce M., Mathias, Rasika A., Becker, Diane M., Peyser, Patricia A., Smith, Jennifer A., Bielinski, Suzette J., Ridker, Paul M., Taylor, Kent D., Yao, Jie, Tracy, Russell, Delgado, Graciela, Trompet, Stella, Sattar, Naveed, Jukema, J. Wouter, Becker, Lewis C., Kardia, Sharon L. R., Rotter, Jerome I., März, Winfried, Dörr, Marcus, Chasman, Daniel I., Dehghan, Abbas, O’Donnell, Christopher J., Smith, Nicholas L., Peters, Annette, Morrison, Alanna C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510421/
https://ncbi.nlm.nih.gov/pubmed/31075152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216222
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