Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease

BACKGROUND: Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not...

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Publicado en:PLoS One
Autores principales: Ward-Caviness, Cavin K., de Vries, Paul S., Wiggins, Kerri L., Huffman, Jennifer E., Yanek, Lisa R., Bielak, Lawrence F., Giulianini, Franco, Guo, Xiuqing, Kleber, Marcus E., Kacprowski, Tim, Groß, Stefan, Petersman, Astrid, Davey Smith, George, Hartwig, Fernando P., Bowden, Jack, Hemani, Gibran, Müller-Nuraysid, Martina, Strauch, Konstantin, Koenig, Wolfgang, Waldenberger, Melanie, Meitinger, Thomas, Pankratz, Nathan, Boerwinkle, Eric, Tang, Weihong, Fu, Yi-Ping, Johnson, Andrew D., Song, Ci, de Maat, Moniek P. M., Uitterlinden, André G., Franco, Oscar H., Brody, Jennifer A., McKnight, Barbara, Chen, Yii-Der Ida, Psaty, Bruce M., Mathias, Rasika A., Becker, Diane M., Peyser, Patricia A., Smith, Jennifer A., Bielinski, Suzette J., Ridker, Paul M., Taylor, Kent D., Yao, Jie, Tracy, Russell, Delgado, Graciela, Trompet, Stella, Sattar, Naveed, Jukema, J. Wouter, Becker, Lewis C., Kardia, Sharon L. R., Rotter, Jerome I., März, Winfried, Dörr, Marcus, Chasman, Daniel I., Dehghan, Abbas, O’Donnell, Christopher J., Smith, Nicholas L., Peters, Annette, Morrison, Alanna C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510421/
https://ncbi.nlm.nih.gov/pubmed/31075152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216222
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