Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease

BACKGROUND: Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ward-Caviness, Cavin K., de Vries, Paul S., Wiggins, Kerri L., Huffman, Jennifer E., Yanek, Lisa R., Bielak, Lawrence F., Giulianini, Franco, Guo, Xiuqing, Kleber, Marcus E., Kacprowski, Tim, Groß, Stefan, Petersman, Astrid, Davey Smith, George, Hartwig, Fernando P., Bowden, Jack, Hemani, Gibran, Müller-Nuraysid, Martina, Strauch, Konstantin, Koenig, Wolfgang, Waldenberger, Melanie, Meitinger, Thomas, Pankratz, Nathan, Boerwinkle, Eric, Tang, Weihong, Fu, Yi-Ping, Johnson, Andrew D., Song, Ci, de Maat, Moniek P. M., Uitterlinden, André G., Franco, Oscar H., Brody, Jennifer A., McKnight, Barbara, Chen, Yii-Der Ida, Psaty, Bruce M., Mathias, Rasika A., Becker, Diane M., Peyser, Patricia A., Smith, Jennifer A., Bielinski, Suzette J., Ridker, Paul M., Taylor, Kent D., Yao, Jie, Tracy, Russell, Delgado, Graciela, Trompet, Stella, Sattar, Naveed, Jukema, J. Wouter, Becker, Lewis C., Kardia, Sharon L. R., Rotter, Jerome I., März, Winfried, Dörr, Marcus, Chasman, Daniel I., Dehghan, Abbas, O’Donnell, Christopher J., Smith, Nicholas L., Peters, Annette, Morrison, Alanna C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510421/
https://ncbi.nlm.nih.gov/pubmed/31075152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216222
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