The interaction between fibrinogen and zymogen FXIII-A(2)B(2) is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits

Coagulation transglutaminase factor XIII (FXIII) exists in circulation as heterotetrameric proenzyme FXIII-A(2)B(2). Effectively all FXIII-A(2)B(2) circulates bound to fibrinogen, and excess FXIII-B(2) circulates in plasma. The motifs that mediate interaction of FXIII-A(2)B(2) with fibrinogen have b...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Byrnes, James R., Wilson, Clare, Boutelle, Anthony M., Brandner, Chase B., Flick, Matthew J., Philippou, Helen, Wolberg, Alisa S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2016
Assuntos:
Thrombosis and Hemostasis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064719/
https://ncbi.nlm.nih.gov/pubmed/27561317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-712323
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